Some case reports are starting to come in that Suboxone can reduce Testosterone levels in some patients and lead to symptomatic difficulties. A recent paper in the Journal of Addiction Medicine reported on 10 such cases. The patients usually had symptoms of fatigue, weight gain and sexual difficulties that had begun after their Suboxone was started. The patients all had low blood levels of Testosterone. Some patients were in their 20s and in some cases the patients developed the problem less than 6 months after their treatment began.
This is not too surprising because other long acting opiates are known to cause this problem. In the 1970s, reports first came out about low Testosterone levels in some patients on Methadone maintenance. Since then other long acting opiates have been shown to cause this problem. At this point it is not clear how common this problem is, and how best to deal with it.